Yes, the U3 Launchpad is now compatible with Windows Vista.

All disgo U3 Smart drives ship with default version (1.0.5.17). To make the disgo compatible with Windows Vista you need to upgrade the Launchpad to version 1.4.0.2

There are 2 methods to access the download. As a precaution, before upgrading please ensure all your information and U3 Smart Applications are backed up and that you have the appropriate license codes.

Using the U3 LaunchpadClick on U3 icon
Click on Status and Settings button
Click on U3 Launchpad Settings button
Click on Check for Software Updates button
Download from the U3 Update page directly

U3 Updater