Answer:
Mac/Linux compatibility:

For Linux:
As of June 2008, all new IronKey devices support Linux kernel 2.6+ for encrypted storage. IronKey devices do not include applications that run on Linux.

For Mac:
The IronKey includes an alpha-level Unlocker for Mac OSX, allowing you to unlock your IronKey on a Mac, though you must initialize it on a Windows XP or Vista machine. An early release required a kext, though the latest release does not .